Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation.

ABSTRACT:

Objectives

This study sought to determine if serum markers for collagen I and III synthesis, the carboxyl terminal peptide from pro-collagen I (PICP) and the amino terminal peptide from pro-collagen III (PIIINP), correlate with left atrial (LA) fibrosis and post-operative atrial fibrillation (AF).

Background

AF after cardiac surgery is associated with adverse outcomes. We recently demonstrated that LA fibrosis is associated with post-operative AF in patients with no previous history of AF.

Methods

Fifty-four patients having cardiac surgery without a history of AF consented to left and right atrial biopsies and a pre-operative peripheral blood draw. Picrosirius red staining quantified the percentage of fibrosis, and reverse transcriptase polymerase chain reaction asses

SUBMITTER: Swartz MF 

PROVIDER: S-EPMC3482337 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature