Vertebrate patatin-like phospholipase domain-containing protein 4 (PNPLA4) genes and proteins: a gene with a role in retinol metabolism

ABSTRACT: At least eight families of mammalian patatin-like phospholipase domain-containing proteins (PNPLA) (E.C. 3.1.1.3) catalyse the hydrolysis of triglycerides, including PNPLA4 (alternatively PLPL4 or GS2), which also acts as a retinol transacylase and participates in retinol-ester metabolism in the body. Bioinformatic methods were used to predict the amino acid sequences, secondary and tertiary structures and gene locations for PNPLA4 genes and encoded proteins using data from several vertebrate genome projects. PNPLA4 genes were located on the X-chromosome for the eutherian mammalian genomes examined. Opossum (marsupial), chicken, anole lizard, clawed toad, zebrafish and lancelet PNPLA4 genes were also identified. Most vertebrate PNPLA4 genes typically contained six coding exons whereas the

SUBMITTER: Holmes R 

PROVIDER: S-EPMC3482448 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature