Liver X receptor and peroxisome proliferator-activated receptor agonist from Cornus alternifolia.

ABSTRACT:

Background

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptors superfamily and are transcription factors activated by specific ligands. Liver X receptors (LXR) belong to the nuclear hormone receptors and have been shown to play an important role in cholesterol homeostasis. From the previous screening of several medicinal plants for potential partial PPARγ agonists, the extracts of Cornus alternifolia were found to exhibit promising bioactivity. In this paper, we report the isolation and structural elucidation of four new compounds and their potential as ligands for PPAR.

Methods

The new compounds were extracted from the leaves of C. alternifolia and fractionated by high-performance liquid chromatography. Their structures were elucidated on the

SUBMITTER: He YQ 

PROVIDER: S-EPMC3482494 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature