Ontology highlight
ABSTRACT:
SUBMITTER: Tussiwand R
PROVIDER: S-EPMC3482832 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Nature 20120919 7421
The AP1 transcription factor Batf3 is required for homeostatic development of CD8α(+) classical dendritic cells that prime CD8 T-cell responses against intracellular pathogens. Here we identify an alternative, Batf3-independent pathway in mice for CD8α(+) dendritic cell development operating during infection with intracellular pathogens and mediated by the cytokines interleukin (IL)-12 and interferon-γ. This alternative pathway results from molecular compensation for Batf3 provided by the relate ...[more]