Vitamin D receptor gene haplotypes and polymorphisms and risk of breast cancer: a nested case-control study.

ABSTRACT:

Background

Observational and experimental studies suggest that vitamin D may influence breast cancer etiology. Most known effects of vitamin D are mediated via the vitamin D receptor (VDR). Few polymorphisms in the VDR gene have been well studied in relation to breast cancer risk and results have been inconsistent.

Methods

We investigated VDR polymorphisms and haplotypes in relation to breast cancer risk by genotyping 26 single nucleotide polymorphisms (SNP) that (i) had known/suspected impact on VDR function, (ii) were tagging SNPs for the three VDR haplotype blocks among whites, or (iii) were previously associated with breast cancer risk. We estimated odds ratios (OR) and 95% confidence intervals (CI) in relation to breast cancer risk among 270 incident cases and 554 match

SUBMITTER: Engel LS 

PROVIDER: S-EPMC3483029 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature