A characterization of the oral microbiome in allogeneic stem cell transplant patients.

ABSTRACT:

Background

The mouth is a complex biological structure inhabited by diverse bacterial communities. The purpose of this study is to describe the effects of allogeneic stem cell transplantation on the oral microbiota and to examine differences among those patients who acquired respiratory complications after transplantation.

Methodology/principal findings

All patients were consented at the National Institutes of Health, Clinical Center. Bacterial DNA was analyzed from patients' oral specimens using the Human Oral Microbe Identification Microarray. The specimens were collected from four oral sites in 45 allogeneic transplantation patients. Specimens were collected at baseline prior to transplantation, after transplantation at the nadir of the neutrophil count and after myeloid

SUBMITTER: Ames NJ 

PROVIDER: S-EPMC3483166 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature