Adaptive evolution of Toll-like receptor 5 in domesticated mammals.

ABSTRACT:

Background

Previous studies have proposed that mammalian toll like receptors (TLRs) have evolved under diversifying selection due to their role in pathogen detection. To determine if this is the case, we examined the extent of adaptive evolution in the TLR5 gene in both individual species and defined clades of the mammalia.

Results

In support of previous studies, we find evidence of adaptive evolution of mammalian TLR5. However, we also show that TLR5 genes of domestic livestock have a concentration of single nucleotide polymorphisms suggesting a specific signature of adaptation. Using codon models of evolution we have identified a concentration of rapidly evolving codons within the TLR5 extracellular domain a site of interaction between host and the bacterial surface protei

SUBMITTER: Smith SA 

PROVIDER: S-EPMC3483281 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature