Explorations of linked editosome domains leading to the discovery of motifs defining conserved pockets in editosome OB-folds.

ABSTRACT: Trypanosomatids form a group of protozoa which contain parasites of human, animals and plants. Several of these species cause major human diseases, including Trypanosoma brucei which is the causative agent of human African trypanosomiasis, also called sleeping sickness. These organisms have many highly unusual features including a unique U-insertion/deletion RNA editing process in the single mitochondrion. A key multi-protein complex, called the ∼20S editosome, or editosome, carries out a cascade of essential RNA-modifying reactions and contains a core of 12 different proteins of which six are the interaction proteins A1 to A6. Each of these interaction proteins comprises a C-terminal OB-fold and the smallest interaction protein A6 has been shown to interact with four other editosome OB-fo

SUBMITTER: Park YJ 

PROVIDER: S-EPMC3483419 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature