Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.

ABSTRACT: Endometrial cancer is the most common gynecological malignancy, with more than 280,000 cases occurring annually worldwide. Although previous studies have identified important common somatic mutations in endometrial cancer, they have primarily focused on a small set of known cancer genes and have thus provided a limited view of the molecular basis underlying this disease. Here we have developed an integrated systems-biology approach to identifying novel cancer genes contributing to endometrial tumorigenesis. We first performed whole-exome sequencing on 13 endometrial cancers and matched normal samples, systematically identifying somatic alterations with high precision and sensitivity. We then combined bioinformatics prioritization with high-throughput screening (including both shRNA-mediate

SUBMITTER: Liang H 

PROVIDER: S-EPMC3483541 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature