Ontology highlight
ABSTRACT:
SUBMITTER: Ouseph MM
PROVIDER: S-EPMC3483796 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Developmental cell 20120401 4
The evolutionarily ancient arm of the E2f family of transcription factors consisting of the two atypical members E2f7 and E2f8 is essential for murine embryonic development. However, the critical tissues, cellular processes, and molecular pathways regulated by these two factors remain unknown. Using a series of fetal and placental lineage-specific cre mice, we show that E2F7/E2F8 functions in extraembryonic trophoblast lineages are both necessary and sufficient to carry fetuses to term. Expressi ...[more]