Different gene expression profiles in normo- and dyslipidemic men after fish oil supplementation: results from a randomized controlled trial.

ABSTRACT:

Background

Epidemiological studies have suggested the benefits of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular health, but only limited data are available describing n-3 PUFA regulated pathways in humans. The aim of this study was to investigate the effects of n-3 PUFA administration on whole genome expression profiles in the blood of normo- and dyslipidemic subjects.

Methods

Differentially expressed genes were detected after four hours, one week and twelve weeks of supplementation with either fish oil (FO) or corn oil in normo- and dyslipidemic men using whole genome microarrays.

Results

Independent of the oil, a significantly higher number of genes was regulated in dyslipidemic subjects compared to normolipidemic subjects. Pathway analyses disco

SUBMITTER: Schmidt S 

PROVIDER: S-EPMC3484010 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature