High expression of p300 is linked to aggressive features and poor prognosis of nasopharyngeal carcinoma.

ABSTRACT:

Background

Increased expression of transcriptional coactivator p300 has been observed in a variety of human cancers. However, the expression status of p300 protein/mRNA in nasopharyngeal carcinoma (NPC) tissues and its clinicopathologic/prognostic implication are poorly understood.

Methods

In our study, mRNA and protein expression levels of p300 was explored by reverse transcription-polymerase chain reaction (RT-PCR), Western blotting (WB) and immunohistochemistry (IHC) in nasopharyngeal mucosal and NPC tissues. The data were analyzed by receiver operating characteristic (ROC) curve analysis, spearman's rank correlation, Kaplan-Meier plots and Cox proportional hazards regression model.

Results

Up-regulated expression of p300 mRNA/p300 protein was detected in NPC tissu

SUBMITTER: Liao ZW 

PROVIDER: S-EPMC3484019 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature