Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation.

ABSTRACT: Bronchiolitis obliterans syndrome (BOS) is a condition of progressive airflow obstruction that affects a majority of lung transplant recipients and limits long-term posttransplant survival. Although epithelial injury appears central to the development of BOS, little is known regarding the specific epithelial cell types that are affected in this condition. We hypothesized that BOS would involve preferential injury to the secretory Clara cells that function in innate defense and epithelial repair. To test this hypothesis, we assessed tissue transcript, tissue protein and lung fluid protein expression of Clara cell secretory protein (CCSP), a marker for Clara cells, in lung transplant recipients with BOS, BOS-free patients and in donor controls. Our results demonstrate that CCSP tissue transc

SUBMITTER: Kelly FL 

PROVIDER: S-EPMC3484196 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature