Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.

ABSTRACT:

Background

Heart failure is a growing cause of morbidity and mortality. Cardiac phosphatidylinositol 3-kinase signaling promotes cardiomyocyte survival and function, but it is paradoxically activated in heart failure, suggesting that chronic activation of this pathway may become maladaptive. Here, we investigated the downstream phosphatidylinositol 3-kinase effector, serum- and glucocorticoid-regulated kinase-1 (SGK1), in heart failure and its complications.

Methods and results

We found that cardiac SGK1 is activated in human and murine heart failure. We investigated the role of SGK1 in the heart by using cardiac-specific expression of constitutively active or dominant-negative SGK1. Cardiac-specific activation of SGK1 in mice increased mortality, cardiac dysfunction, and ve

SUBMITTER: Das S 

PROVIDER: S-EPMC3484211 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature