On the role of PDZ domain-encoding genes in Drosophila border cell migration.

ABSTRACT: Cells often move as collective groups during normal embryonic development and wound healing, although the mechanisms governing this type of migration are poorly understood. The Drosophila melanogaster border cells migrate as a cluster during late oogenesis and serve as a powerful in vivo genetic model for collective cell migration. To discover new genes that participate in border cell migration, 64 out of 66 genes that encode PDZ domain-containing proteins were systematically targeted by in vivo RNAi knockdown. The PDZ domain is one of the largest families of protein-protein interaction domains found in eukaryotes. Proteins that contain PDZ domains participate in a variety of biological processes, including signal transduction and establishment of epithelial apical-basal polarity. Targetin

SUBMITTER: Aranjuez G 

PROVIDER: S-EPMC3484668 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature