Mediators of a long-term movement abnormality in a Drosophila melanogaster model of classic galactosemia.

ABSTRACT: Despite neonatal diagnosis and life-long dietary restriction of galactose, many patients with classic galactosemia grow to experience significant long-term complications. Among the more common are speech, cognitive, behavioral, ovarian and neurological/movement difficulties. Despite decades of research, the pathophysiology of these long-term complications remains obscure, hindering prognosis and attempts at improved intervention. As a first step to overcome this roadblock we have begun to explore long-term outcomes in our previously reported GALT-null Drosophila melanogaster model of classic galactosemia. Here we describe the first of these studies. Using a countercurrent device, a simple climbing assay, and a startle response test to characterize and quantify an apparent movement abnormal

SUBMITTER: Ryan EL 

PROVIDER: S-EPMC3484862 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature