The response of human skin commensal bacteria as a reflection of UV radiation: UV-B decreases porphyrin production.

ABSTRACT: Recent global radiation fears reflect the urgent need for a new modality that can simply determine if people are in a radiation risk of developing cancer and other illnesses. Ultraviolet (UV) radiation has been thought to be the major risk factor for most skin cancers. Although various biomarkers derived from the responses of human cells have been revealed, detection of these biomarkers is cumbersome, probably requires taking live human tissues, and varies significantly depending on human immune status. Here we hypothesize that the reaction of Propionibacterium acnes (P. acnes), a human resident skin commensal, to UV radiation can serve as early surrogate markers for radiation risk because the bacteria are immediately responsive to radiation. In addition, the bacteria can be readily access

SUBMITTER: Wang Y 

PROVIDER: S-EPMC3485044 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature