Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.

ABSTRACT: Major depressive disorder is a common global disease that causes a significant societal burden. Most interventional studies of depression provide a limited assessment of the interventions on mortality and suicide risks. This study utilizes data from an observational registry of patients with major depressive disorder to determine the impact of intervention (vagus nerve stimulation or standard pharmacological/non-pharmacological therapy) and a latent factor, patient trajectory toward response, on mortality, suicide and suicidal ideation. A total of 636 patients were available for an intent-to-treat analysis of all-cause mortality, suicide and suicidal ideation. Patients treated with vagus nerve stimulation in addition to standard therapies experienced lower, but not statistically significan

SUBMITTER: Olin B 

PROVIDER: S-EPMC3485051 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature