DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.

ABSTRACT:

Background

The effect of referring patients from a clinical setting to a pragmatic exercise intervention for depressive symptoms, cognitive function, and metabolic variables has yet to be determined.

Methods

Outpatients with major depression (DSM-IV) were allocated to supervised aerobic or stretching exercise groups during a three months period. The primary outcome was the Hamilton depression score (HAM-D(17)). Secondary outcomes were cognitive function, cardiovascular risk markers, and employment related outcomes.

Results

56 participants were allocated to the aerobic exercise intervention versus 59 participants to the stretching exercise group. Post intervention the mean difference between groups was -0.78 points on the HAM-D(17) (95% CI -3.2 to 1.6; P = .52). At fol

SUBMITTER: Krogh J 

PROVIDER: S-EPMC3485141 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature