Neural correlates of true and false memory in mild cognitive impairment.

ABSTRACT: The goal of this research was to investigate the changes in neural processing in mild cognitive impairment. We measured phase synchrony, amplitudes, and event-related potentials in veridical and false memory to determine whether these differed in participants with mild cognitive impairment compared with typical, age-matched controls. Empirical mode decomposition phase locking analysis was used to assess synchrony, which is the first time this analysis technique has been applied in a complex cognitive task such as memory processing. The technique allowed assessment of changes in frontal and parietal cortex connectivity over time during a memory task, without a priori selection of frequency ranges, which has been shown previously to influence synchrony detection. Phase synchrony differed sig

SUBMITTER: Sweeney-Reed CM 

PROVIDER: S-EPMC3485202 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature