Modeling 18F-FDG kinetics during acute lung injury: experimental data and estimation errors.

ABSTRACT:

Background

There is increasing interest in Positron Emission Tomography (PET) of 2-deoxy-2-[18F]flouro-D-glucose ((18)F-FDG) to evaluate pulmonary inflammation during acute lung injury (ALI). We assessed the effect of extra-vascular lung water on estimates of (18)F-FDG-kinetics parameters in experimental and simulated data using the Patlak and Sokoloff methods, and our recently proposed four-compartment model.

Methodology/principal findings

Eleven sheep underwent unilateral lung lavage and 4 h mechanical ventilation. Five sheep received intravenous endotoxin (10 ng/kg/min). Dynamic (18)F-FDG PET was performed at the end of the 4 h period. (18)F-FDG net uptake rate (Ki), phosphorylation rate (k(3)), and volume of distribution (F(e)) were estimated in three isogravitational re

SUBMITTER: Dittrich AS 

PROVIDER: S-EPMC3485257 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature