Autoregulation of RNA helicase expression in response to temperature stress in Synechocystis sp. PCC 6803.

ABSTRACT: RNA helicases are ubiquitous enzymes whose modification of RNA secondary structure is known to regulate RNA function. The pathways controlling RNA helicase expression, however, have not been well characterized. Expression of the cyanobacterial RNA helicase, crhR, is regulated in response to environmental signals that alter the redox poise of the electron transport chain, including light and temperature. Here we analyze crhR expression in response to alteration of abiotic conditions in wild type and a crhR mutant, providing evidence that CrhR autoregulates its own expression through a combination of transcriptional and post-transcriptional mechanisms. Temperature regulates crhR expression through alteration of both transcript and protein half-life which are significantly extended at low tem

SUBMITTER: Rosana AR 

PROVIDER: S-EPMC3485376 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature