Palladium-catalyzed N-monoarylation of amidines and a one-pot synthesis of quinazoline derivatives.

ABSTRACT: A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also demonstrated.

SUBMITTER: McGowan MA 

PROVIDER: S-EPMC3485433 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature