A quantitative meta-analysis of population-based studies of premorbid intelligence and schizophrenia.

ABSTRACT:

Objective

A premorbid IQ deficit supports a developmental dimension to schizophrenia and its cognitive aspects that are crucial to functional outcome. Better characterisation of the association between premorbid IQ and the disorder may provide further insight into its origin and etiology. We aimed to quantify premorbid cognitive function in schizophrenia through systematic review and meta-analysis of longitudinal, population-based studies, and to characterize the risk of schizophrenia across the entire range of premorbid IQ.

Method

Electronic and manual searches identified general population-based cohort or nested case-control studies that measured intelligence before onset of schizophrenic psychosis using standard psychometric tests, and that defined cases using contemporan

SUBMITTER: Khandaker GM 

PROVIDER: S-EPMC3485562 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature