Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice.

ABSTRACT: Alzheimer's disease (AD) is characterized by a progressive memory decline and numerous pathological abnormalities, including amyloid β (Aβ) accumulation in the brain and synaptic dysfunction. Here we wanted to study whether these brain changes were associated with alteration in the population of monocyte subsets since accumulating evidence supports the concept that the innate immune system plays a role in the etiology of this disease. We then determined the immune profile together with expression of genes encoding synaptic proteins and neurotrophins in APP(Swe)/PS1 mice and their age-matched wild-type (WT) littermates. We found that the progressive cognitive decline and the dramatic decrease in the expression of numerous synaptic markers and neurotrophins correlated with a major defect in

SUBMITTER: Naert G 

PROVIDER: S-EPMC3485573 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature