Variations in the potassium channel genes KCNK3 and KCNK9 in relation to blood pressure and aldosterone production: an exploratory study.

ABSTRACT:

Context

Two potassium (K) channel genes, Kcnk3 and Kcnk9, when deleted in mice, produced a model of hyperaldosteronism and hypertension.

Objective

Our objective was to explore genetic variation [single-nucleotide polymorphisms (SNP)] in KCNK3 and KCNK9 in relation to blood pressure (BP) and aldosterone production in humans.

Subjects and study design

Two groups of healthy European Americans (EA) and African Americans (AA) were studied: 1) a longitudinal study group (age ∼14 yr when enrolled, 444 EA and 351 AA) and 2) an inpatient cross-sectional study group (age ∼23 yr, 85 EA and 109 AA). Plasma renin activity, plasma aldosterone concentration, and level of serum K were measured cross-sectionally; BP was measured semiannually in the longitudinal study. SNP were selecte

SUBMITTER: Jung J 

PROVIDER: S-EPMC3485591 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature