Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity.

ABSTRACT:

Context

A central/visceral fat distribution and excess free fatty acid (FFA) availability are associated with dyslipidemia and insulin resistance. However, these two characteristics often coexist, making it difficult to detect the independent contributions of each. Whether FFA suppression is more closely linked to metabolic abnormalities is not clear.

Objective

The aim of the study was to examine the relationship between FFA suppression, body fat distribution, and fitness as contributors toward insulin resistance and hypertriglyceridemia.

Design

We measured systemic palmitate turnover using an iv infusion of [9,10-(3)H]palmitate; upper body sc adipose tissue (UBSQ) and visceral adipose tissue (VAT) with dual-energy x-ray absorptiometry and a single-slice abdominal com

SUBMITTER: Bush NC 

PROVIDER: S-EPMC3485612 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature