Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis.

ABSTRACT:

Background

Many growth factors, such as bone morphogenetic protein (BMP)-2, have been shown to interact with polymers of sulfated disacharrides known as heparan sulfate (HS) glycosaminoglycans (GAGs), which are found on matrix and cell-surface proteoglycans throughout the body. HS GAGs, and some more highly sulfated forms of chondroitin sulfate (CS), regulate cell function by serving as co-factors, or co-receptors, in GF interactions with their receptors, and HS or CS GAGs have been shown to be necessary for inducing signaling and GF activity, even in the osteogenic lineage. Unlike recombinant proteins, however, HS and CS GAGs are quite heterogenous due, in large part, to post-translational addition, then removal, of sulfate groups to various positions along the GAG polymer. We hav

SUBMITTER: Decarlo AA 

PROVIDER: S-EPMC3485628 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature