SPO71 mediates prospore membrane size and maturation in Saccharomyces cerevisiae.

ABSTRACT: The mechanisms that control the size and shape of membranes are not well understood, despite the importance of these structures in determining organelle and cell morphology. The prospore membrane, a double lipid bilayer that is synthesized de novo during sporulation in S. cerevisiae, grows to surround the four meiotic products. This membrane determines the shape of the newly formed spores and serves as the template for spore wall deposition. Ultimately, the inner leaflet of the prospore membrane will become the new plasma membrane of the cell upon germination. Here we show that Spo71, a pleckstrin homology domain protein whose expression is induced during sporulation, is critical for the appropriate growth of the prospore membrane. Without SPO71, prospore membranes surround the nuclei but

SUBMITTER: Parodi EM 

PROVIDER: S-EPMC3485916 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature