Global transcriptional analysis of dehydrated Salmonella enterica serovar Typhimurium.

ABSTRACT: Despite the scientific and industrial importance of desiccation tolerance in Salmonella, knowledge regarding its genetic basis is still scarce. In the present study, we performed a transcriptomic analysis of dehydrated and water-suspended Salmonella enterica serovar Typhimurium using microarrays. Dehydration induced expression of 90 genes and downregulated that of 7 genes. Ribosomal structural genes represented the most abundant functional group with a relatively higher transcription during dehydration. Other main induced functional groups included genes involved in amino acid metabolism, energy production, ion transport, transcription, and stress response. The highest induction was observed in the kdpFABC operon, encoding a potassium transport channel. Knockout mutations were generated in

SUBMITTER: Gruzdev N 

PROVIDER: S-EPMC3485933 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature