Analysis of the regulated transcriptome of Neisseria meningitidis in human blood using a tiling array.

ABSTRACT: Neisseria meningitidis is the major cause of septicemia and meningococcal meningitis. During the course of infection, the bacterium must adapt to different host environments as a crucial factor for survival and dissemination; in particular, one of the crucial factors in N. meningitidis pathogenesis is the ability to grow and survive in human blood. We recently showed that N. meningitidis alters the expression of 30% of the open reading frames (ORFs) of the genome during incubation in human whole blood and suggested the presence of fine regulation at the gene expression level in order to control this step of pathogenesis. In this work, we used a customized tiling oligonucleotide microarray to define the changes in the whole transcriptional profile of N. meningitidis in a time course experim

SUBMITTER: Del Tordello E 

PROVIDER: S-EPMC3486417 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature