Evolutionary analysis of human immunodeficiency virus type 1 therapies based on conditionally replicating vectors.

ABSTRACT: Efforts to reduce the viral load of human immunodeficiency virus type 1 (HIV-1) during long-term treatment are challenged by the evolution of anti-viral resistance mutants. Recent studies have shown that gene therapy approaches based on conditionally replicating vectors (CRVs) could have many advantages over anti-viral drugs and other approaches to therapy, potentially including the ability to circumvent the problem of evolved resistance. However, research to date has not explored the evolutionary consequences of long-term treatment of HIV-1 infections with conditionally replicating vectors. In this study, we analyze a computational model of the within-host co-evolutionary dynamics of HIV-1 and conditionally replicating vectors, using the recently proposed 'therapeutic interfering particle

SUBMITTER: Ke R 

PROVIDER: S-EPMC3486895 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature