Exploring population admixture dynamics via empirical and simulated genome-wide distribution of ancestral chromosomal segments.

ABSTRACT: The processes of genetic admixture determine the haplotype structure and linkage disequilibrium patterns of the admixed population, which is important for medical and evolutionary studies. However, most previous studies do not consider the inherent complexity of admixture processes. Here we proposed two approaches to explore population admixture dynamics, and we demonstrated, by analyzing genome-wide empirical and simulated data, that the approach based on the distribution of chromosomal segments of distinct ancestry (CSDAs) was more powerful than that based on the distribution of individual ancestry proportions. Analysis of 1,890 African Americans showed that a continuous gene flow model, in which the African American population continuously received gene flow from European populations ov

SUBMITTER: Jin W 

PROVIDER: S-EPMC3487126 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature