Bioconjugation of green fluorescent protein via an unexpectedly stable cyclic sulfonium intermediate.

ABSTRACT: Smooth converter: Bioconjugation of superfolder GFP involving the formation of an unusually stable, and unprecedented, cyclic sulfonium species is described. This sulfonium can undergo smooth reaction with a range of nucleophiles to give sulfur-, selenium- and azide-modified GFP derivatives in high conversions.

SUBMITTER: Nathani R 

PROVIDER: S-EPMC3487180 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature