Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival.

ABSTRACT:

Background

Although the role of microRNA's (miRNA's) biogenesis pathway genes in cancer development and progression has been well established, the association between genetic variants of this pathway genes and breast cancer survival is still unknown.

Methods

We used genotype data available from a previously conducted case-control study to investigate association between common genetic variations in miRNA biogenesis pathway genes and breast cancer survival. We investigated the possible associations between 41 germ-line single-nucleotide polymorphisms (SNPs) and both disease free survival (DFS) and overall survival (OS) among 488 breast cancer patients. During the median follow-up of 6.24 years, 90 cases developed disease progression and 48 cases died.

Results

Seven SNP

SUBMITTER: Sung H 

PROVIDER: S-EPMC3487887 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature