Gene expression anti-profiles as a basis for accurate universal cancer signatures.

ABSTRACT:

Background

Early screening for cancer is arguably one of the greatest public health advances over the last fifty years. However, many cancer screening tests are invasive (digital rectal exams), expensive (mammograms, imaging) or both (colonoscopies). This has spurred growing interest in developing genomic signatures that can be used for cancer diagnosis and prognosis. However, progress has been slowed by heterogeneity in cancer profiles and the lack of effective computational prediction tools for this type of data.

Results

We developed anti-profiles as a first step towards translating experimental findings suggesting that stochastic across-sample hyper-variability in the expression of specific genes is a stable and general property of cancer into predictive and diagnostic si

SUBMITTER: Bravo HC 

PROVIDER: S-EPMC3487959 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature