Quantitative proteomics in teleost fish: insights and challenges for neuroendocrine and neurotoxicology research.

ABSTRACT: Neuroendocrine systems integrate both extrinsic and intrinsic signals to regulate virtually all aspects of an animal's physiology. In aquatic toxicology, studies have shown that pollutants are capable of disrupting the neuroendocrine system of teleost fish, and many chemicals found in the environment can also have a neurotoxic mode of action. Omics approaches are now used to better understand cell signaling cascades underlying fish neurophysiology and the control of pituitary hormone release, in addition to identifying adverse effects of pollutants in the teleostean central nervous system. For example, both high throughput genomics and proteomic investigations of molecular signaling cascades for both neurotransmitter and nuclear receptor agonists/antagonists have been reported. This review

SUBMITTER: Martyniuk CJ 

PROVIDER: S-EPMC3488193 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature