Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study.

ABSTRACT:

Background

An association between infections and vascular events has been observed, but the specific effect of influenza and influenza-like illnesses on triggering acute myocardial infarction (AMI) is unclear.

Methods

Episodes of first AMI from 1 January 2003 through 31 July 2009 were identified using linked anonymized electronic medical records from the Myocardial Ischaemia National Audit Project and the General Practice Research Database. Self-controlled case series analysis was used to investigate AMI risks after consultation for acute respiratory infection. Infections were stratified by influenza virus circulation, diagnostic code, and vaccination status to assess whether influenza was more likely than other infections to trigger AMI.

Results

Of 22,024 patients wi

SUBMITTER: Warren-Gash C 

PROVIDER: S-EPMC3488196 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature