Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI.

ABSTRACT:

Objective

To examine the neural basis of cognitive complaints in healthy older adults in the absence of memory impairment and to determine whether there are medial temporal lobe (MTL) gray matter (GM) changes as reported in Alzheimer disease (AD) and amnestic mild cognitive impairment (MCI).

Methods

Participants were 40 euthymic individuals with cognitive complaints (CCs) who had normal neuropsychological test performance. The authors compared their structural brain MRI scans to those of 40 patients with amnestic MCI and 40 healthy controls (HCs) using voxel-based morphometry and hippocampal volume analysis.

Results

The CC and MCI groups showed similar patterns of decreased GM relative to the HC group on whole brain analysis, with differences evident in the MTL, front

SUBMITTER: Saykin AJ 

PROVIDER: S-EPMC3488276 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature