Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction.

ABSTRACT:

Background

The signaling mechanisms that regulate the recruitment of bone marrow (BM)-derived cells to the injured heart are not well known. Notch receptors mediate binary cell fate determination and may regulate the function of BM-derived cells. However, it is not known whether Notch1 signaling in BM-derived cells mediates cardiac repair after myocardial injury.

Methods and results

Mice with postnatal cardiac-specific deletion of Notch1 exhibit infarct size and heart function after ischemic injury that is similar to that of control mice. However, mice with global hemizygous deletion of Notch1 (N1(±)) developed larger infarct size and worsening heart function. When the BM of N1(±) mice were transplanted into wild-type (WT) mice, infarct size and heart function were worsened

SUBMITTER: Li Y 

PROVIDER: S-EPMC3488350 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature