A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis.

ABSTRACT:

Background

We previously identified a functional variant in a let-7 microRNA (miRNA) complementary site in the 3'-untranslated region of the KRAS oncogene (rs61764370) which is associated with cancer. We aimed to investigate the association of this KRAS variant with breast cancer and tumour biology.

Methods

We assessed frequency distributions of the KRAS variant in 415 patients with histologically confirmed breast cancer and 457 controls from Connecticut, USA (study group 1) and association of this variant with breast-cancer subtypes in 690 Irish women with known oestrogen receptor (ER), progesterone receptor (PR), and HER2 statuses, and 360 controls (study group 2). We pooled data for study groups 1 and 2 with a cohort of 140 women with triple-negative breast cancer and 113

SUBMITTER: Paranjape T 

PROVIDER: S-EPMC3488438 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature