Biomimetic Synthesis of Cbz-(S)-Dolaphenine.

ABSTRACT: A new route to Cbz-(S)-dolaphenine, a recurring element in bioactive peptidic natural products, has been implemented, which closely parallels the biogenetic pathway. Cyclodehydration of 11 to yield thiazoline 2 allows for a Ni(0)-promoted decarbonylative aromatization to provide the thiazole framework with retention of stereochemistry.

SUBMITTER: Garcia-Reynaga P 

PROVIDER: S-EPMC3488445 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature