Plasma choline metabolites associate with metabolic stress among young overweight men in a genotype-specific manner.

ABSTRACT:

Objectives

We aimed to test the hypotheses that (i) plasma choline metabolites differ between normal (body mass index (BMI)<25 kg m(-2)) and overweight (BMI 25 kg m(-2)) men, and (ii) an elevated BMI alters associations between plasma choline metabolites and indicators of metabolic stress.

Design

This was a cross-sectional study. A one-time fasting blood sample was obtained for measurements of the choline metabolites and metabolic stress indicators (that is, serum alanine aminotransferase (ALT), glucose, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides and homocysteine), and for genotype determination.

Subjects

The analysis was conducted with 237 Mexican American men with a median age of 22 years.

Results

Compared with m

SUBMITTER: Yan J 

PROVIDER: S-EPMC3488811 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature