Clinical analysis of perioperative complement activity during ischemia/reperfusion injury following renal transplantation.

ABSTRACT:

Background and objectives

The complement cascade seems to be an important mediator modulating renal ischemia/reperfusion injury. This study analyzed whether significant changes occur in the levels of a terminal panel of complement molecules (C3a, C5a, and C5b-9/membrane attack complex) during the early phase of human kidney allograft reperfusion and evaluated the potential association of these changes with clinical post-transplant graft function in kidney transplant recipients.

Design, setting, participants, & measurements

Seventy-five renal transplant recipients undergoing transplantation between 2004 and 2006 were enrolled in the study and divided into early, slow, and delayed graft function groups. Blood samples were collected perioperatively during consecutive minutes of

SUBMITTER: Blogowski W 

PROVIDER: S-EPMC3488944 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature