Gene-Diet Interactions in Complex Disease: Current Findings and Relevance for Public Health.

ABSTRACT: Rates of obesity and related complex diseases such as type 2 diabetes and cardiovascular disease have climbed sharply over the past decades, in parallel with shift from principally more active lifestyle and nutritionally dense tradition diet to sedentary lifestyle and more energy-dense, Western-pattern diet. In the past few years, advances in genotyping technology and in particular a number of large-scale genome-wide association studies have made great strides in unraveling the genetic basis of complex diseases; and the growing inventory of genetic variation is facilitating efforts to investigate gene-diet interactions. Understanding gene-diet interaction has the potential to promote diet modifications on the basis of genetic makeup. Several recent large-scale studies found reproducible ev

SUBMITTER: Qi L 

PROVIDER: S-EPMC3489189 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature