Cytokine/chemokine patterns connect host and viral characteristics with clinics during chronic hepatitis C.

ABSTRACT:

Background

In chronic hepatitis C virus (HCV) infection, liver tissue pathology and HCV genotype are important determinants of clinical and/or treatment-related outcome. Although consistent epidemiological and/or molecular-biological clues derived from different studies on single virus-host interactions are meanwhile published, the in vivo transcriptional responses and cellular pathways affected in >1 key aspects of the disease or treatment process are far from being understood.

Methods

Microarray analysis was performed in peripheral whole blood (PB) samples from 36 therapy-naïve HCV-infected patients with known liver histology. Linear regression analysis identified gene expression profiles significantly correlating (P < 0.015) with ≥1 out of 7 variables: sustained viral res

SUBMITTER: Katsounas A 

PROVIDER: S-EPMC3489717 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature