Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody.

ABSTRACT: Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells.

SUBMITTER: Houot R 

PROVIDER: S-EPMC3489758 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature