TRPV6 and Calbindin-D9k-expression and localization in the bovine uterus and placenta during pregnancy.

ABSTRACT:

Background

Transient receptor potential channel type 6 (TRPV6) and Calbindin-D9k (CaBP-9k) are involved in the active calcium (Ca2+) transport mechanism in many tissues including placenta and uterus, suggesting a role in the establishment and maintenance of pregnancy. Moreover, TRPV6 and CaBP-9k seem to support the materno-fetal Ca2+ transport that is crucial for fetal Ca2+ homeostasis, bone growth and development. However, it is unknown if these proteins are also involved in the aetiology of pathologies associated with parturition in cows, such as retained fetal membranes (RFM). The aim of the current study was to create an expression profile of uterine and placentomal TRPV6 and CaBP-9k mRNAs and proteins during pregnancy and postpartum in cows with and without fetal membrane rele

SUBMITTER: Sprekeler N 

PROVIDER: S-EPMC3489777 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature