Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.

ABSTRACT: Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases. Placenta, as a widely recognized programming agent, contibutes to the underlying processes. According to our previous findings, a high-fat diet during gestation triggers sex-specific epigenetic alterations within CpG and throughout the genome, together with the deregulation of clusters of imprinted genes. We further investigated the impact of diet and sex on placental histology, transcriptomic and epigenetic signatures in mice. Both basal gene expression and response to maternal high-fat diet were sexually dimorphic in whole placentas. Numerous genes showed sexually dimorphic expression, but only 11 genes regardless of the diet. In line wi

SUBMITTER: Gabory A 

PROVIDER: S-EPMC3489896 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature