Magnetic resonance lymphangiography with a nano-sized gadolinium-labeled dendrimer in small and large animal models.

ABSTRACT:

Aim

Imaging of the lymphatic system is critical in preoperative planning of resections of complex lymphatic malformations. However, safe, effective imaging methods with sufficient resolution to identify the lymphatics have been lacking. In this study, we demonstrate the use of gadolinium-labeled dendrimers to image the lymphatics in small and large animal models during magnetic resonance lymphangiography.

Methods

Polyamidoamine G6-Gd_1B4M_N-hydroxysuccinimide was synthesized and administered intradermally in the extremities of normal mice and pigs at several doses.

Results

The lymphatics were well demonstrated in both animal models and there was rapid uptake in the deep lymphatic system, including the thoracic duct. A significant dose reduction was achieved (1 µmol Gd

SUBMITTER: Sena LM 

PROVIDER: S-EPMC3489937 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature